Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
J. Kaiser, C. G. W. Gertzen, T. Bernauer, V. Nitsche, G. Höfner, K. V. Niessen, T. Seeger, F. F. Paintner, K. T. Wanner, D. Steinritz, F. Worek, H. Gohlke
This paper identifies novel ligands binding to MB327-PAM-1, a binding site for resensitizing nAChRs, including cycloguanil, which shows higher affinity and functional efficacy.
bioRxiv · Dec 21, 2023Pharmacology & Toxicology