Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution
A. Escobedo, G. Voigt, A. J. Faure, B. Lehner
The paper evaluates the stability and function of randomized hydrophobic protein cores across evolutionary distances, finding that allostery disrupts function despite stable cores.
bioRxiv · May 11, 2024 · PreprintBiophysics