BioinformaticsbioRxivPreprint
A deep learning approach for rational affinity maturation of anti-VEGF nanobodies
Gaëlle Verdon, Laurent David, Alexandre G. de Brevern, Yasser Mohseni Behbahani
This study uses deep learning to design anti-VEGF nanobodies with improved affinity and stability through structure-guided mutational modeling and a sequence-based melting temperature predictor.
DOI 10.1101/2025.10.20.683442