Theory for Biomolecular Catalysis in Phase-Separated Systems
Gaetano Granatelli, Samuel Santhosh Gomez, Sudarshana Laha, Thomas C. T. Michaels, Christoph A. Weber
The paper develops a quantitative theory of enzymatic catalysis in phase-separated systems, showing condensates can act as tunable catalytic switches with optimal activity at biologically relevant sizes.
bioRxiv · Aug 19, 2026 · PreprintBiophysics