Christoph A. Weber

The paper develops a quantitative theory of enzymatic catalysis in phase-separated systems, showing condensates can act as tunable catalytic switches with optimal activity at biologically relevant sizes.

This study shows membrane curvature drives prewetting transitions that organize mitochondrial nucleoids through localized protein condensation.

The paper shows how coupling enzymatic reactions to phase separation creates self-regulating compartments that modulate mRNA stability and levels.

This study investigates how membrane binding influences 2D versus 3D phase separation of the protein FUS, showing that membrane binding allows 2D condensates to form at lower concentrations than bulk phase separation.

This study demonstrates spatio-temporal oscillations in synthetic cells through a size control mechanism that converts chemical fuel into waste, sustaining oscillations for hundreds of periods.

This paper develops a thermodynamic model of non-dilute surface binding and phase separation for membrane-binding proteins and applies it to tight junction formation.

The paper derives a model for molecular transport across phase boundaries in coexisting liquid phases and identifies two physical scenarios that lead to an effective transport resistance.