The hepatic sinusoid is a site of microvascular complications of hyperglycemia
Cristina I Oie, Gianina Dumitriu, Ruomei Li, Gahl Levy
This study identifies the hepatic sinusoid as a site of microvascular complications of hyperglycemia, showing that glucose-induced damage to liver sinusoidal endothelial cells (LSECs) through the hexosamine pathway and O-GlcNAcylation leads to capillarization and liver disease.
bioRxiv · Oct 18, 2026 · PreprintCell Biology