CILP from Cartilage Intermediate Zone Inhibits Hyaline Cartilage Fibrosis and Chondrocyte Ferroptosis via Keap1-Nrf2 Axis in Early Osteoarthritis Exercise Therapy
Shuangshuo Jia, Zhehan Hu, Zihan Li, Weiming Zhang, Liang Chen, Changping Niu, Ziqi Zhao, Yuhan Sun, Gang Yao, Yang Wang, Yue Yang
The paper investigates how moderate exercise in early OA rats upregulates CILP in the cartilage intermediate zone, inhibiting fibrosis and ferroptosis via the Keap1-Nrf2 axis.
Cellular and Molecular Life Sciences · Mar 23, 2026Peer-reviewedCell Biology