Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in mice.
Darko Stevanović, Alex J. Hebert, Bhavna N. Desai, Garima Singhal, Andrew Charles Adams, Jeffrey S. Flier, Eleftheria Maratos–Flier
This study shows that FGF21 suppresses fructose preference in mice but not glucose or sucrose, and this effect requires central β-klotho expression.
bioRxiv · Jan 27, 2020 · PreprintMolecular Biology