A Deformulating Multi-Attribute SEC Method for Simultaneous Quantification of Total RNA, Conjugated Antibody, and Free Antibody in Targeted Lipid Nanoparticles
Jeremy R Filteau, Anastasiya P Manuilov, Garret M Rubin, Hui Zhou, Paroma Ghosh, Mohui Wei, Liang Zu, Himanshu Dhamankar, Peter Bernhardt
This paper introduces an online deformulating SE-HPLC method to simultaneously quantify total RNA, conjugated antibody, and free antibody in targeted lipid nanoparticles.
bioRxiv · Nov 9, 2026 · PreprintBiophysics