Skin DNA Methylation Encodes Multidimensional Facial Aging Phenotypes with Distinct Biological Architectures
Varun Bhamidipati Dwaraka, Sayf Al-Deen Hassouneh, Kirsten Seale, Dua Sheikh, Jordan Weiter, Joseph C. Gretzula, Raja K. Sivamani, Anastasia Georgievskaya, Konstantin Kiselev, Gary M. Fisher, Yilei Cui, Lavinia Propescu, Ryan C. Smith
The paper develops EpiVision, a panel of 21 epigenetic predictors linking skin DNA methylation to facial aging traits, revealing shared and trait-specific biological pathways.
bioRxiv · Mar 16, 2026 · PreprintGenomics