Kirsten Seale

This study examines how portable-sauna use affects DNA methylation in firefighters' whole blood, identifying potential epigenetic changes linked to aging and health.

The paper develops a reproducibility-based framework for creating DNA methylation algorithms on the MSA, showing that stable probe sets can support new biomarkers and transfer of existing ones with improved performance.

This study evaluates how epigenetic clocks respond to fasting and refeeding, finding that some clocks show significant shifts while others remain stable, highlighting the importance of immune cell composition and study design.

The paper develops EpiVision, a panel of 21 epigenetic predictors linking skin DNA methylation to facial aging traits, revealing shared and trait-specific biological pathways.

The paper develops Biolearn, an open-source framework for curating and evaluating aging biomarkers across datasets, finding that harmonization and standardization improve their performance and generalizability.

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

This study identifies 48% differentially methylated positions and 37% variably methylated positions in blood methylomes across aging, revealing their roles in entropy and epigenetic clocks.

This paper uses DNA methylation data to analyze immune cell fractions across 25,629 blood samples, identifying associations with age, sex, health outcomes, and lifestyle factors.

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.