Multimodal physical evidence uncovers interpretable gene regulatory networks for perturbation prediction
Zhiwen Yang, Sikai Huang, Ge Bai, Jintong Dong, Jue Wang, Stan Z. Li
The paper introduces VitaGRN, a multimodal biophysical framework that predicts perturbation responses and uncovers non-canonical regulatory mechanisms, demonstrating robust generalization across cell lines and factors.
bioRxiv · Jun 7, 2026 · PreprintBioinformatics