Estimate of disease heritability using 7.4 million familial relationships inferred from electronic health records
Fernanda C. G. Polubriaginof, Rami Sesha Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary C. Simmerling, George Hripcsak, Suzanne Bakken Henry, , Nicholas P. Tatonetti
The paper uses next-of-kin data from electronic health records to estimate heritability for 500 disease phenotypes, finding results consistent with existing literature.
bioRxiv · May 24, 2017 · PreprintGenetics