Swedish APP follows distinct neuronal traffickingitineraries that underlie its increased Aβ-cleavage
Cameron R. Plowinske, Sarah Tedesco, Alec T. Nabb, Geraldine B. Quinones, Marvin Bentley
This study shows that Swedish APP (APPSwe) follows distinct neuronal trafficking routes compared to wild-type APP, leading to increased Aβ production.
bioRxiv · Aug 24, 2026 · PreprintCell Biology