Direct Amide Bond Formation By A Spore Peptidoglycan Biosynthetic Enzyme
Madison E. Hopkins, Zachary Yasinov, Mark J. Fakler, Grace E. Wilde, Katherine G. Wetmore, Michael A. Welsh
This study identifies SwsB as a muramic-δ-lactam cyclase that forms amide bonds without requiring metal ions or energy input, revealing a novel enzymatic mechanism in spore peptidoglycan biosynthesis.
bioRxiv · Mar 28, 2025 · PreprintBiochemistry