Acute testicular hyperthermia leads to a rapid loss of global piRNA levels and a consequent increase in transcript abundance, including LINE1 activity within heat-sensitive male germ cells.
Benjamin R. Robinson, Jacob Kendal Netherton, Rachel Anne Ogle, Sean M. Burnard, Grace E. Williams, Georgia M. Tennant, Heather J Lee, Mark A. Baker
This study shows testicular hyperthermia rapidly reduces piRNA levels and increases LINE1 activity in male germ cells, leading to DNA damage and potential infertility.
bioRxiv · Mar 30, 2025 · PreprintMolecular Biology