Sean M. Burnard

MINT Block integrates multi-omics data across studies to identify generalisable signatures while accounting for study-specific variation, improving prediction accuracy.

This study identifies X-chromosome hypomethylation in female MS patients and links it to XCI escape genes and immune processes.

This study shows testicular hyperthermia rapidly reduces piRNA levels and increases LINE1 activity in male germ cells, leading to DNA damage and potential infertility.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

The paper introduces scTEM-seq to profile DNA methylation and transcriptomes in single cells, finding DNA methylation heterogeneity linked to gene expression and transposable element activity in AML cells.