Na+/K+-ATPase Blockade Reversibly Attenuates Proliferation and Metabolic Function in K562 Human Myelogenous Leukemia Cells
Simon R Bowden, Eli T Colton, Amber D Norgaard, McKenzie M Haas, Erynn R Dunnigan, Carly J Goven, Grace O Goven, Thomas J Hinnenkamp, Keagan D Walker, Theresa M Ballance, Blaise I Kathol, Elizabeth R. Murphy, Kristian Van Slyke, Rylie Webb, Ashlin Schaefbauer, Joseph P. Biggane
This study shows that blocking Na+/K+-ATPase with digoxin reduces proliferation and metabolic function in K562 leukemia cells, with effects reversible upon drug removal.
bioRxiv · Sep 19, 2026 · PreprintCancer Biology