Mendelian Randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
Eleonora Porcu, Sina Rüeger, Kaido Lepik, Mawussé D. T. Agbessi, Habibul Ahsan, Isabel Alves, Anand Kumar Andiappan, Wibowo Arindrarto, Philip Awadalla, Alexis J. Battle, Frank Beutner, Marc Jan Bonder, Dorret Irene Boomsma, Mark W. Christiansen, Annique Claringbould, , René Luijk
This paper introduces TWMR, a Mendelian Randomization method that identifies gene-trait associations by integrating GWAS and eQTL data, revealing 3,913 novel associations across 43 human phenotypes.
Nature Communications · Jul 24, 2019Peer-reviewedGenetics