Luke R. Lloyd‐Jones

Validation-free estimation of chronological age via close-kin

The paper estimates chronological age without known-age individuals by modeling half-sibling pair occurrence rates and capture times using a pseudo-likelihood framework.

Improved polygenic prediction by Bayesian multiple regression on summary statistics

This paper introduces SBayesR, a Bayesian method for polygenic prediction using GWAS summary statistics, achieving higher accuracy and efficiency than existing methods.

Bayesian analysis of GWAS summary data reveals differential signatures of natural selection across human complex traits and functional genomic categories

The effect of X-linked dosage compensation on complex trait variation

The paper examines how X-linked dosage compensation affects genetic variation in complex traits, finding more genetic variation in males than females for X-linked loci.

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

This study identifies 139 common and 4 rare genetic variants associated with type 2 diabetes through GWAS and integrates gene expression and epigenomic data to highlight potential functional genes and regulatory mechanisms.

Widespread signatures of negative selection in the genetic architecture of human complex traits

The paper estimates the joint distribution of effect size and MAF for genetic variants in 28 complex traits and detects widespread negative selection signatures.

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

This study shows that multi-site regulation of gene expression leads to biased eQTL fine mapping and highlights the need for joint multi-site analysis to improve accuracy.