Bernett Teck Kwong Lee

Brain defence by the extracellular matrix protein Cochlin

This study identifies Cochlin as an extracellular matrix protein produced in brain barriers that enhances immune defence against bacterial infection in zebrafish.

A chromosome-scale Plasmodium cynomolgi Berok genome reveals a distinct subtelomeric architecture and a highly diverged primate malaria lineage

High-throughput plasma proteomic platforms: Insights from a multi-ethnic Asian cohort

The paper compares three proteomic platforms in a multi-ethnic Asian cohort, finding limited overlap, platform-specific performance metrics, and ethnicity-related protein differences.

Tirzepatide reduces diet-induced senescence and NETosis-mediated liver fibrosis in mice

This study shows tirzepatide reduces diet-induced liver fibrosis by decreasing lipofuscin accumulation and NETosis in mice.

Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age

This study shows that choline supplementation during pregnancy improves cognitive health in mice during pregnancy and in old age, with lasting effects on hippocampal gene signatures.

A Domain-Specific Language Model Approach for Identifying Immunogenic Epitopes from Publicly Available Data: EpitopeMiner

EpitopeMiner identifies immunogenic epitopes using a domain-specific LLM with RAG, improving retrieval of relevant literature and supporting neoantigen validation.

OTTERS: A powerful TWAS framework leveraging summary-level reference data

OTTERS is a TWAS framework that uses summary-level eQTL reference data to estimate eQTL weights and perform omnibus TWAS, showing improved power and applicability.

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

The paper uses blood eQTL meta-analysis to explore the polygenic architecture of complex traits, finding that trans-eQTLs are more informative for identifying causal genes than cis-eQTLs.

Mendelian Randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

This paper introduces TWMR, a Mendelian Randomization method that identifies gene-trait associations by integrating GWAS and eQTL data, revealing 3,913 novel associations across 43 human phenotypes.

Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes

This study identifies 139 common and 4 rare genetic variants associated with type 2 diabetes through GWAS and integrates gene expression and epigenomic data to highlight potential functional genes and regulatory mechanisms.

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

The paper identifies gene targets for brain-related traits using transcriptomic and methylomic data from blood, finding strong correlations between genetic effects in brain and blood tissues.