Whole organism lineage tracing by combinatorial and cumulative genome editing
Aaron McKenna, Gregory Findlay, James A Gagnon, Marshall Horwitz, Alexander Franz F Schier, Jay Shendure
This study introduces a genome editing method to trace whole organism lineages by accumulating mutations in DNA barcodes, showing that most adult zebrafish cells originate from few embryonic progenitors.
bioRxiv · May 11, 2016Developmental Biology