Chronic Electronic Cigarette Exposure Promotes Atherosclerosis and Chondrogenic Modulation of Smooth Muscle Cells
Isabella Damiani, Chad S. Weldy, Quanyi Zhao, Elena Hurtado Solberg, Guyu Tracy Qin, Meena Easwaran, Siwen Zheng, Sugandha Basu, Wenduo Gu, Matthew D. Worssam, João P. Monteiro, Daniel Yuhang Li, Gurmenjit Kaur Bahia, Ramendra Krishna Kundu, Trieu Nguyen, , Juyong Brian Kim
This study shows chronic e-cigarette exposure accelerates atherosclerosis by reprogramming smooth muscle cells toward a chondrogenic phenotype through GRIN2A-dependent NMDAR signaling.
bioRxiv · Sep 13, 2025 · PreprintGenomics