Juyong Brian Kim

An in vitro System for Studying Osteochondrogenic Differentiation of Smooth Muscle Cells and Modeling Intimal Vascular Calcification

This paper develops an in vitro system that mimics osteochondrogenic differentiation of smooth muscle cells and intimal vascular calcification, showing distinct transcriptional states compared to standard calcification assays.

Immune Aging is an Independent Risk Factor for Cardiovascular Disease

The paper introduces IMM-AGE, a metric of immune-aging, and shows it independently predicts cardiovascular disease risk across multiple cohorts.

A cell and transcriptome atlas of human arterial vasculature

This study creates a transcriptomic and spatial atlas of human arterial segments, revealing cell-type and segment-specific heterogeneity linked to vascular disease risk.

Chronic Electronic Cigarette Exposure Promotes Atherosclerosis and Chondrogenic Modulation of Smooth Muscle Cells

This study shows chronic e-cigarette exposure accelerates atherosclerosis by reprogramming smooth muscle cells toward a chondrogenic phenotype through GRIN2A-dependent NMDAR signaling.

Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

The paper identifies causal genetic mechanisms at CAD GWAS loci using CRISPR screens and chromatin analysis, revealing enhancer-gene links and ancestry/sex-specific risk factors.

Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis

This study shows dioxin exposure accelerates atherosclerosis by promoting inflammatory smooth muscle cell phenotypes and oxidative stress, with AHR in SMC providing protective effects.

Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci

The paper maps QTLs for TCF21 binding, chromatin accessibility, and chromosomal looping in coronary artery smooth muscle cells and links them to CAD GWAS loci.

The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions

The paper investigates the role of AHR in atherosclerosis by showing it suppresses chondrogenic fate of modulated smooth muscle cells in lesions.

LncRNA de novo discovery reveals noncoding RNAs as major molecular mechanism associating coronary artery disease GWAS variants with causal genes to confer disease risk

The paper identifies noncoding RNAs as key mediators linking coronary artery disease GWAS variants to causal genes.