Author

Guus van Zadelhoff

Utrecht University

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ashvani K. SinghiD· 1 shared Aya M. Saleh· 1 shared Azib Hagos· 1 shared Chris TseiD· 1 shared Corina BalutiD· 1 shared David J. Hardee· 1 shared Henry Korman· 1 shared Huan-Qiu Li· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ashvani K. SinghORCID

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1 paper

Recent·Most cited

A new corrector rescues F508del-CFTR folding through stabilization of the TMD1-NBD1 linker

Peter van der Sluijs, Olga Papaioannou, Azib Hagos, Aya M. Saleh, Timothy R. Hodges, Corina Balut, Matthew Green, Sara Alani, Yihong Fan, Kazumi Ebine, Michael R. Schrimpf, David J. Hardee, Huan-Qiu Li, Henry Korman, Laura Tade, , Ineke Braakman

This paper introduces X307810, a new C2 corrector that significantly improves F508del-CFTR folding and function by stabilizing the TMD1-NBD1 linker, achieving 80% wild-type levels.

bioRxiv · Mar 10, 2025 · PreprintBiochemistry