BiochemistrybioRxivPreprint
A new corrector rescues F508del-CFTR folding through stabilization of the TMD1-NBD1 linker
Peter van der Sluijs, Olga Papaioannou, Azib Hagos…·Ineke Braakman
This paper introduces X307810, a new C2 corrector that significantly improves F508del-CFTR folding and function by stabilizing the TMD1-NBD1 linker, achieving 80% wild-type levels.
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