Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis
Jean Fan, Neeraj Salathia, Rui Liu, Gwen Kaeser, Yun Yung, Joseph L Herman, Fiona Kaper, Jian-Bing Fan, Kun Zhang, Jerold Chun, Peter Kharchenko
This study introduces PAGODA, a method to detect transcriptional heterogeneity by analyzing pathway and gene set overdispersion, and applies it to characterize neuronal progenitors in the developing mouse cortex.
Nature Methods · Jan 18, 2016Peer-reviewedGenomics