Rui Liu

H3K4me3 recruits the chromatin remodeling DILL-PICKLE-PEPPERCORN complexes to promoters in plants

This study identifies PKL complexes in plants that recognize H3K4me3 and regulate gene expression at promoters through chromatin remodeling.

SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism

This study shows SARS-CoV-2 ORF3a disrupts lysosomal cholesterol export by interfering with VPS39-regulated NPC2 trafficking and BMP metabolism.

Membrane-anchored influenza neuraminidase vaccine drives human-like broadly protective B cell responses

This study develops a membrane-anchored influenza neuraminidase vaccine that elicits human-like broadly protective B cell responses and cross-inhibitory activity against diverse NA variants.

A Modularized Stretchable Microneedle Array for Minimally Invasive and Efficient Drug Delivery

The paper develops a modularized stretchable microneedle array for efficient drug delivery, showing improved penetration rates and reduced residual strain in porcine skin.

Development and Characterization of a Tunable PDMS Substrate Model for Investigating Elastic Properties and Mechanical Stretching in Intervertebral Disc Cells

This paper develops a tunable PDMS substrate platform to study mechanical loading and cell-substrate interactions in intervertebral disc cells, showing cells align with applied strain and maintain viability.

Assessing the measurement transfer function of single-cell RNA sequencing

This study evaluates the performance of three scRNA-seq methods through controlled experiments, finding they reliably detect genes above 5-10 molecules with linear measurement transfer functions.

PARAQUAT TOLERANCE3 is an E3 ligase and acts as a negative regulator of oxidative stress response

The paper identifies PQT3 as an E3 ligase that negatively regulates the oxidative stress response by targeting PRMT4b for degradation.

Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis

This study introduces PAGODA, a method to detect transcriptional heterogeneity by analyzing pathway and gene set overdispersion, and applies it to characterize neuronal progenitors in the developing mouse cortex.