Conserved early steps of stemmadenine biosynthesis
Mohamed Omar Kamileen, Yoko Nakamura, Marlen Sigmund, Radhika Keshan, Veit Grabe, Sarah Heinicke, Maritta Kunert, Benke Hong, Ryan M. Alam, Gyumin Kang, Lorenzo Caputi, Sarah Ellen O'Connor
The paper identifies and characterizes stemmadenine acetate pathway genes from Tabernanthe iboga, reconstitutes the biosynthesis in Nicotiana benthamiana, and identifies shunt products affecting pathway flux.
Journal of Biological Chemistry · Dec 30, 2025Peer-reviewedBiochemistry