Author

H. Aligireddy

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. N. Reeb· 1 shared D. D. Dhavale· 1 shared J. Bieschke· 1 shared N. Kedia· 1 shared P. T. Kotzbauer· 1 shared R. L. French· 1 shared Y. M. Ayala· 1 shared Z. R. Grese· 1 shared

Activity by Year

2018-2018 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

A. N. Reeb

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1 paper

Recent·Most cited

TDP-43 oligomers detected as initial intermediate species during aggregate formation

R. L. French, A. N. Reeb, H. Aligireddy, N. Kedia, D. D. Dhavale, Z. R. Grese, P. T. Kotzbauer, J. Bieschke, Y. M. Ayala

This study identifies TDP-43 oligomers as early intermediates in aggregation, showing ALS-linked mutations accelerate this process and enhance aggregate propagation.

bioRxiv · Dec 17, 2018 · PreprintBiochemistry