CLPX regulates erythroid heme synthesis by control of mitochondrial heme synthesis enzymes and iron utilization
C. M. Rondelli, M. Perfetto, A. Danoff, H. Bergonia, S. Gillis, G. Nicolas, H. Puy, R. West, J. D. Phillips, Y. Y. Yien
This study shows CLPX regulates erythroid heme synthesis by controlling ALAS2 stability, PPOX activity, and iron metabolism, with its role not conserved across eukaryotes.
bioRxiv · Sep 9, 2020 · PreprintBiochemistry