A Deformulating Multi-Attribute SEC Method for Simultaneous Quantification of Total RNA, Conjugated Antibody, and Free Antibody in Targeted Lipid Nanoparticles
Jeremy R Filteau, A. P. Manuilov, G. M. Rubin, H. Zhou, P. Ghosh, M. Wei, L. Zu, H. Dhamankar, P. Bernhardt
This paper introduces an online deformulating SE-HPLC method to simultaneously quantify total RNA, conjugated antibody, and free antibody in targeted lipid nanoparticles.
bioRxiv · Nov 9, 2026 · PreprintBiophysics