3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
K. L. Mortenson, C. Dawes, E. R. Wilson, N. Patchen, H. E. Johnson, J. Gertz, S. D. Bailey, Y. Liu, K. E. Varley, X. Zhang
The paper introduces HAPI, a 3D genomics method, to identify enhancer hijacking in cancer cell lines, revealing novel oncogene activation mechanisms.
bioRxiv · Jan 23, 2024Cancer Biology