Author

K. L. Mortenson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

J. Gertz· 2 shared X. Zhang· 2 shared A. J. Lazar· 1 shared A. Pozner· 1 shared B. Jensen· 1 shared C. Dawes· 1 shared C. John· 1 shared C. S. Hughes· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

J. Gertz

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2 papers

Recent·Most cited

3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression

K. L. Mortenson, C. Dawes, E. R. Wilson, N. Patchen, H. E. Johnson, J. Gertz, S. D. Bailey, Y. Liu, K. E. Varley, X. Zhang

The paper introduces HAPI, a 3D genomics method, to identify enhancer hijacking in cancer cell lines, revealing novel oncogene activation mechanisms.

bioRxiv · Jan 23, 2024Cancer Biology

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

A. Pozner, S. P. Verma, L. Li, S. Wang, J. J. Barrott, M. L. Nelson, J. S. E. Yu, G. L. Negri, S. Colborne, C. S. Hughes, J.-F. Zhu, S. L. Lambert, L. S. Carroll, K. Smith-Fry, M. G. Stewart, , K. B. Jones

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

bioRxiv · Sep 29, 2023Cancer Biology