Identification of CD4+ Sub-population of Resident Cardiac Fibroblasts Linked to Myocardial Fibrosis
J. H. Siamwala, F. Pagano, P. M. Dubielecka, A. Zhao, S. Chen, H. Granston, S. Rounds, S. Sadayappan, R. J. Gilbert
The paper identifies a CD4+ subpopulation of resident cardiac fibroblasts linked to myocardial fibrosis, showing their transdifferentiation from mesenchymal to lymphoid-like cells via the IL-1β-IL-1R-NFκB pathway.
bioRxiv · Feb 26, 2021 · PreprintImmunology