Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety
D. X. Sato, Y. U. Inoue, Y. Morimoto, T. Inoue, N. Kuga, T. Sasaki, Y. Ikegaya, K. Nomoto, T. Kikusui, S. Hattori, G. Sala, H. Hagihara, T. Miyakawa, M. Kawata
This study introduces humanized Vmat1 mutations into mice to investigate their impact on anxiety-related behaviors and amygdala function, finding reduced anxiety and altered neurophysiological activity.
bioRxiv · May 18, 2021Evolutionary Biology