Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells
T. Ohno, T. Akase, S. Kono, H. Kurasawa, T. Takashima, Y. Aizawa
The paper introduces UKiS, a genome substitution platform for biallelic and gene-wide mutagenesis in human cells, demonstrating its ability to modify introns and retroelements.
bioRxiv · Mar 9, 2022Bioengineering