Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of congenital myasthenic syndrome
Jarred Lau, Stephanie F. Gaudreau, K. K. Palacek, Sally Spendiff, Tuan Vu Bui, H. Lochmüller
The paper validates an optogenetic approach in zebrafish to study fatigable muscle weakness and NMJ function in CMS models, linking behavior, electrophysiology, and genetics.
bioRxiv · Jun 4, 2026 · PreprintNeuroscience