Conformational flexibility Of A Highly Conserved Helix Controls Cryptic Pocket Formation In FtsZ
A. Alnami, R. S. Norton, H. P. Pena, S. Haider, F. Kozielski
The paper identifies cryptic pockets in M. tuberculosis FtsZ that bind coumarin analogues, revealing how conformational flexibility of the H7 helix enables these interactions.
bioRxiv · Sep 8, 2020Microbiology