Conformational dynamics of FERM-mediated autoinhibition in Pyk2 tyrosine kinase.
H. S. Loving, E. S. Underbakke
This study investigates the conformational dynamics of FERM-mediated autoinhibition in Pyk2 tyrosine kinase using HDX-MS and kinase activity profiling, revealing key interfaces and allosteric links.
bioRxiv · Jun 24, 2019Biochemistry