The dynamic equilibrium of nascent and parental MCMs safeguards replicating genomes
H. Sedlackova, M.-B. D. Rask, R. Gupta, C. Choudhary, K. Somyajit, J. Lukas
This paper investigates how MCM2-7 complexes are maintained across cell divisions to ensure genome stability, finding that MCMBP facilitates the nuclear import of nascent MCM3-7 subunits to sustain pre-RC formation.
bioRxiv · Nov 2, 2019Cell Biology