gamma aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammation
S. Kang, L. Liu, T. Wang, M. Cannon, P. Lin, T. W.- M. Fan, D. A. Scott, H.-J. J. Wu, A. N. Lane, R. Wang
This study shows GAB controls T cell inflammation by acting as a bioenergetic and signaling gatekeeper through ABAT-dependent anaplerosis and GABA(A) receptor-mediated autocrine signaling.
bioRxiv · Feb 17, 2022 · PreprintImmunology