Author

T. W.- M. Fan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Assay:metabolomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. N. Lane· 3 shared L. Liu· 3 shared R. Wang· 3 shared S. Kang· 3 shared T. Wang· 3 shared D. A. Scott· 2 shared J. R. Gnanaprakasam· 2 shared T. A. Cassel· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. N. Lane

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3 papers

Recent·Most cited

ImmunologyScience ImmunologyPeer-reviewedApr 15, 2022

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

X. Chen, B. Sunkel, M. Wang…·R. Wang

This study shows that succinate dehydrogenase/complex II is essential for T cell proliferation and inflammation by regulating metabolic flux and epigenetic modifications.

DOI 10.1126/sciimmunol.abm8161

humanmetabolomics

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 17, 2022

gamma aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammation

S. Kang, L. Liu, T. Wang…·R. Wang

This study shows GAB controls T cell inflammation by acting as a bioenergetic and signaling gatekeeper through ABAT-dependent anaplerosis and GABA(A) receptor-mediated autocrine signaling.

DOI 10.1101/2022.02.17.480926

mousemetabolomics

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 14, 2019

Inosine is an alternative carbon supply that supports effector T cell proliferation and anti-tumor function under glucose restriction

T. Wang, J. R. Gnanaprakasam, X. Chen…·R. Wang

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

DOI 10.1101/766642

humanmetabolomics

𝕏 PostBluesky