Microbiota-derived TMAO links PM2.5 exposure to cognitive impairment: A gut liver brain axis
Hussain Akhlaq, Yunxiao Zhong, Shicong Du, Zonghao Ma, Tong Cheng, Jiasui Yu, Lee Cheuk Hin, Douglas Affonso Formolo, Patrick K. H. Lee, Baomin Wang, Kenneth King‐Yip Cheng, Siu-Wai Wan, Daniel Kam‐Wah Mok, Jiachi Amber Chiou, Xiangdong Li, , Suk‐Yu Yau
This study shows PM2.5 exposure causes cognitive impairment via the gut-liver-brain axis, mediated by TMAO-induced ER stress in the hippocampus.
bioRxiv · May 28, 2026 · PreprintAnimal Behavior & Cognition