Complete biosynthesis of penicillin G in Nicotiana benthamiana
Abdul Rawoof, Yen Tung Lin, Sanjeevan Rajendran, Gaëlle Antoine, Sameera Jayasundara, Yingqi Cai, Digar Singh, Payton Whitehead, Haley Dornberger, Sonya Mall, Ana Paula Alonso, Michael C. Carroll, Elizabeth Skellam, Kent Dean Chapman
This study engineers Nicotiana benthamiana to produce penicillin G by expressing fungal biosynthetic genes, demonstrating successful subcellular localization without additional engineering.
bioRxiv · May 10, 2026 · PreprintSynthetic Biology