Gradual repression of selenoprotein W ensures physiological bone remodelling
Hyunsoo Kim, Kyunghee Lee, Jin Man Kim, Jae-Ryong Kim, Han-Woong Lee, Youn Wook Chung, Hong-In Shin, Eui-Soon Park, Jaerang Rho, Seoung Hoon Lee, Nacksung Kim, Soo Young Lee, Yongwon Choi, Daewon Jeong
This study identifies SELENOW as a regulator of osteoclast differentiation and bone remodelling, showing its repression by RANKL signaling prevents osteoporosis.
bioRxiv · Jan 26, 2018 · PreprintPhysiology