Veillonella dispar triggers dual-hits in the pathogenesis of autoimmune hepatitis and primary biliary cholangitis via testosterone depletion-BAFF-B cell axis and Th17 cell activation
Ya-Ling Liu, Qing-Qing Xing, Xiang Lin, Weiwei Zeng, Yin-Hong Chen, Yan-Ying You, Lina Zhou, Xiaoning Chen, Minxia Wu, Han-Xin Xue, Shangeng Weng, Jin‐Shui Pan
This study shows Veillonella dispar induces autoimmune liver disease by reducing testosterone and increasing BAFF, leading to B cell expansion and Th17 activation, which differentiate AIH and PBC.
bioRxiv · Oct 1, 2026 · PreprintImmunology