Xiang Lin

Veillonella dispar triggers dual-hits in the pathogenesis of autoimmune hepatitis and primary biliary cholangitis via testosterone depletion-BAFF-B cell axis and Th17 cell activation

This study shows Veillonella dispar induces autoimmune liver disease by reducing testosterone and increasing BAFF, leading to B cell expansion and Th17 activation, which differentiate AIH and PBC.

scDILT: a model-based and constrained deep learning framework for single-cell Data Integration, Label Transferring, and clustering

scDILT integrates single-cell datasets while preserving reference clustering patterns and mapping new cells to annotated clusters, outperforming existing methods on simulated and real data.

Signals in the Cells: Multimodal and Contextualized Machine Learning Foundations for Therapeutics

The paper introduces Therapeutics Commons (TDC-2), a resource integrating cell-type-specific biomarkers with machine learning tasks for drug discovery.