Coordinating the in vivo processes for minicircle production - a novel approach to large scale manufacturing
Peter Mayrhofer, Hana Jug, Aleš Štrancar, Alexandre Di Paolo, Laurent Jost, Alice Zimmermann, Heinz Redl
The paper describes a new approach to improve the efficiency of minicircle-DNA production for gene therapy by integrating advanced in vivo process coordination and downstream purification techniques.
bioRxiv · Apr 15, 2018 · PreprintBioengineering