Pathway impact analysis (PIS) for robust and comprehensive interpretation of differentially expressed genes (DEGs)
Yeogha Yoon, Minji An, Hanbi Lee, Wankyu Kim
The paper introduces PIS, a method to improve DEG selection by optimizing thresholds for pathway enrichment, showing better recovery of true DEGs and stability across datasets.
bioRxiv · Sep 8, 2025 · PreprintBioinformatics